IGF-DES – 1mg

IGF-DES (Des(1-3)IGF-1) is a truncated analogue of Insulin Like Growth Factor 1 (IGF-1), produced by the removal of the first three amino acids from the N-terminal sequence of the native IGF-1 structure. iLab Pharma’s formulation supplies 1mg as a lyophilized vial, a standard research unit for IGF analogues where precise low concentration handling is a critical variable. Preserving peptide structural integrity and potency across storage conditions until reconstitution.

The N-terminal truncation that defines IGF-DES produces a pharmacologically distinct compound from native IGF-1 in a research relevant way. Full length IGF-1 binds extensively to insulin like growth factor binding proteins (IGFBPs) in circulation, which sequester a significant fraction of administered compound and reduce the proportion available for IGF-1 receptor binding. The removal of the first three amino acids in IGF-DES dramatically reduces IGFBP binding affinity; estimated at approximately 1000 fold reduction compared to native IGF-1. While preserving near complete IGF-1 receptor binding activity. This combination of reduced IGFBP sequestration and maintained receptor affinity produces a significantly higher free bioavailable fraction per administered dose than equivalent native IGF-1, making IGF-DES a frequently studied research tool in comparative IGF bioavailability and receptor binding studies.

IGF-DES also demonstrates notably higher potency at the IGF-1 receptor than native IGF-1 in cell culture research models; a characteristic attributed to its reduced IGFBP competition allowing more direct receptor access. Research has documented IGF-DES activity across muscle cell proliferation and differentiation, neuronal survival and growth, and tissue repair pathways. Its enhanced receptor availability profile making it particularly valuable in studies examining IGF-1 receptor signaling mechanisms at lower concentration points than native IGF-1 research typically requires. The 1mg format supports precise titration based research across the dose response curve for this high potency IGF analogue.

iLab Pharma formulations are stocked by Canada Steroid Depot following the same rigorous third party lab verification process applied to every product in our range. Each batch is tested for concentration accuracy and purity before being made available, with COA documentation available on request. CSD’s sourcing standards apply uniformly across all manufacturers we carry, and iLab Pharma’s IGF-DES meets those standards consistently. All orders ship discreetly across Canada in plain, unmarked packaging with no identifying information on the exterior.

Reconstitute with bacteriostatic water prior to use. Store lyophilized peptide at 2–8°C away from direct light. Once reconstituted refrigerate and use within 28 days. Intended for research purposes only.

Commonly researched alongside IGF-1 LR3 in comparative insulin like growth factor bioavailability and receptor binding studies. Browse CSD’s full peptide range for complete sourcing.