Anti Aging

Anti-Aging & Longevity Compounds in Canada | Senolytics, NAD+ Pathway, Peptides & mTOR Inhibitors

Canada Steroid Depot's anti-aging category covers the most actively researched longevity compound classes in current geoscience research. From NAD+ pathway restoration and mitochondrial support, to senolytic compounds that selectively eliminate senescent cells, to peptide bioregulators that modulate gene expression in ageing tissues, to mTOR inhibitors that extend lifespan in multiple animal models. Each compound class targets a distinct hallmark of ageing, and many are researched in combination protocols for synergistic longevity effects.

NAD+ pathway restoration | NMN, NR and injectable NAD+

Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme central to mitochondrial energy production, DNA repair via PARP activation, and sirtuin mediated gene expression regulation. NAD+ levels decline by approximately 50% between ages 40 and 60, contributing to reduced cellular energy, impaired DNA repair, mitochondrial dysfunction, and accelerated cellular ageing. Research into NAD+ restoration focuses on three primary approaches: direct NAD+ administration via injection or nasal spray for maximum bioavailability; NMN (Nicotinamide Mononucleotide) supplementation as an immediate NAD+ precursor; and NR (Nicotinamide Riboside) as an alternative precursor with a distinct metabolic pathway. CSD stocks all three formats with injectable NAD+ available for maximum systemic bioavailability.

Peptide bioregulators | Epithalon, Thymalin and GHK-Cu

Peptide bioregulators are short chain peptides that modulate gene expression in specific tissues, studied extensively by Russian researchers over four decades for their effects on biological age markers and tissue function restoration. Epithalon (Epitalon) is a tetrapeptide studied for its ability to stimulate telomerase activity. The enzyme responsible for maintaining telomere length, alongside antioxidant, melatonin modulating, and anti tumor properties in animal models. Thymalin is a thymic peptide bioregulator studied for immune system restoration in ageing subjects. GHK-Cu (Copper peptide) is a naturally occurring tripeptide studied for its effects on collagen synthesis, wound healing, anti inflammatory signaling, and gene expression modulation with over 4,000 genes identified as responsive to GHK-Cu in research settings.

Senolytics | Targeting senescent cells

Cellular senescence; the accumulation of dysfunctional cells that resist apoptosis and secrete pro inflammatory molecules (the SASP) is one of the most studied hallmarks of ageing. Senolytic compounds selectively induce apoptosis in senescent cells while leaving healthy cells intact, reducing the chronic low grade inflammation (inflammaging) associated with the ageing process. The most researched senolytic combination is Dasatinib + Quercetin (D+Q), which has demonstrated senescent cell clearance and functional improvements in multiple animal models and early human trials. Fisetin is a naturally occurring flavonoid with potent senolytic activity studied as a more accessible alternative to Dasatinib.

mTOR inhibitors and caloric restriction mimetics

The mechanistic target of rapamycin (mTOR) pathway is one of the most conserved longevity pathways across species with mTOR inhibition consistently extending lifespan in organisms from yeast to mammals. Rapamycin (Sirolimus) is the most potent and well characterized mTOR inhibitor, demonstrated to extend lifespan by 9–14% in mice even when started in mid life. Metformin, the widely prescribed biguanide, activates AMPK and indirectly inhibits mTOR while also modulating the gut microbiome and reducing systemic IGF-1 — making it the most accessible caloric restriction mimetic currently researched for longevity applications. Both compounds are available in CSD's anti-aging catalogue.