5-Amino-1MQ (5 Amino 1 methylquinolinium) is a selective small molecule inhibitor of nicotinamide N-methyltransferase (NNMT); an enzyme that plays a central regulatory role in cellular energy metabolism, adipogenesis, and the methionine cycle. Hudson Science’s formulation supplies 50mg as a lyophilized powder requiring reconstitution prior to use, a format that preserves compound stability and ensures consistent potency across storage and handling conditions for this emerging class of metabolic research compound.

NNMT catalyses the methylation of nicotinamide using S-adenosylmethionine (SAM) as the methyl donor, producing S-adenosylhomocysteine (SAH) and 1 methylnicotinamide as byproducts. By selectively inhibiting NNMT, 5-Amino-1MQ increases the intracellular SAM to SAH ratio — elevating the methyl donor availability that drives downstream methylation reactions across multiple metabolic pathways. This shift in the SAM/SAH ratio has downstream effects on NAD+ biosynthesis, sirtuin enzyme activation, and mitochondrial biogenesis — a cascade of metabolic pathway interactions that has positioned NNMT inhibition as one of the more actively researched targets in obesity, metabolic syndrome, and cellular energy homeostasis research.

5-Amino-1MQ’s documented influence on adipocyte biology is a central focus of the current research literature. NNMT is highly expressed in adipose tissue and has been identified as a key regulator of adipogenesis and fat cell size. Selective inhibition has been associated with suppression of adipocyte differentiation, reduction in lipid accumulation, and upregulation of energy expenditure in preclinical models. Its selectivity for NNMT over related methyltransferase enzymes makes it a valuable tool compound in research isolating NNMT’s specific contribution to metabolic regulation from broader methyltransferase activity.

Hudson Science formulations are stocked by Canada Steroid Depot following the same rigorous third party lab verification process applied to every product in our range. Each batch is tested for concentration accuracy and purity before being made available, with COA documentation available on request. CSD’s sourcing standards apply uniformly across all manufacturers we carry, and Hudson Science’s 5-Amino-1MQ meets those standards consistently. All orders ship discreetly across Canada in plain, unmarked packaging with no identifying information on the exterior.

Reconstitute with bacteriostatic water prior to use. Store lyophilized powder at 2–8°C away from direct light. Once reconstituted refrigerate and use within 28 days. Intended for research purposes only.

Commonly researched alongside NAD+ precursor compounds in metabolic pathway and energy homeostasis studies. Browse CSD’s full peptide and research compound range for complete sourcing.