Enclomiphene Citrate is the trans isomer of Clomiphene Citrate, the pharmacologically active component of standard Clomiphene responsible for the majority of its HPG axis stimulating activity. Isolated and supplied as a pure single isomer compound without the zuclomiphene (cis isomer) fraction that comprises approximately 38% of standard Clomiphene preparations. F40 Biotech’s formulation delivers 12.5mg per tablet in a 50 count format. A precisely dosed low concentration presentation reflecting Enclomiphene’s greater potency per milligram compared to racemic Clomiphene, where the absence of zuclomiphene’s partial estrogen agonist activity produces a cleaner, more selective HPG axis stimulation profile at lower doses.
The pharmacological distinction between Enclomiphene and standard Clomiphene Citrate is the central research differentiator between the two compounds in CSD’s SERM range. Standard Clomiphene is a racemic mixture. Approximately 62% enclomiphene and 38% zuclomiphene; where zuclomiphene’s partial estrogen agonist activity and significantly longer half-life of several weeks produces prolonged estrogenic background activity that persists well beyond the enclomiphene fraction’s clearance. Pure Enclomiphene eliminates this zuclomiphene contribution entirely, delivering selective estrogen receptor antagonism at the hypothalamus and pituitary without the residual estrogenic activity that standard Clomiphene’s isomer mixture introduces. This cleaner antagonist only profile has generated growing research interest in Enclomiphene as a more pharmacologically precise HPG axis stimulation tool compared to racemic Clomiphene, particularly in studies examining the specific contribution of pure estrogen receptor antagonism to LH and FSH secretion stimulation independent of partial agonist confounding.
Enclomiphene’s mechanism of action mirrors the active fraction of Clomiphene. Blocking estrogen’s negative feedback signal on GnRH neurons in the hypothalamus, driving increased GnRH pulsatility and downstream LH and FSH secretion from the pituitary. The clinical development program for isolated Enclomiphene has generated human research data examining testosterone restoration in hypogonadal males with preserved spermatogenesis. Research endpoint where its cleaner isomer profile has produced outcomes distinguishable from racemic Clomiphene in comparative studies, contributing a growing standalone clinical literature base separate from the extensive Clomiphene research history.
F40 Biotech formulations are stocked by Canada Steroid Depot following the same rigorous third party lab verification process applied to every product in our range. Each batch is tested for concentration accuracy and purity before being made available, with COA documentation available on request. CSD stocks both Enclomiphene and racemic Clomiphene Citrate in the SERM range; giving researchers the pure trans isomer and the standard racemic mixture for complete comparative isomer research from a single verified Canadian supplier. All orders ship discreetly across Canada in plain, unmarked packaging with no identifying information on the exterior.
Store in a cool, dry place away from direct light and heat. Intended for research purposes only.
Commonly researched alongside Clomiphene and testosterone compounds in comparative SERM isomer and HPG axis stimulation studies. Browse CSD’s full PCT range for complete sourcing.
