MOTS-C (Mitochondrial Open Reading Frame of the Twelve S rRNA type c) is a mitochondria derived peptide encoded within the mitochondrial genome rather than the nuclear genome; a discovery that fundamentally challenged the long held understanding that the mitochondrial genome’s coding capacity was limited to components of the oxidative phosphorylation machinery. F40 Biotech’s formulation delivers 60mg in a 3mL prefilled pen system, providing a ready to use multi dose delivery format that eliminates the reconstitution preparation steps associated with traditional lyophilized peptide vials and supports consistent dose measurement across extended research protocols.

MOTS-C’s mechanism of action centers on its role as an endogenous regulator of metabolic homeostasis through AMPK (AMP activated protein kinase) pathway activation. By translocating from the mitochondria to the nucleus in response to metabolic stress, MOTS-C directly influences nuclear gene expression. A mitochondria to nucleus signaling pathway that was not previously attributed to mitochondrially encoded peptides. AMPK activation downstream of MOTS-C signaling promotes glucose uptake, fatty acid oxidation, and mitochondrial biogenesis while suppressing anabolic pathways that consume cellular energy. A coordinated metabolic response that has generated significant research interest in studies examining insulin sensitivity, exercise mimetics, and age related metabolic decline.

MOTS-C’s research profile spans multiple areas of current interest in metabolic and longevity science. Its documented decline with age in human plasma has positioned it as a subject of research into mitochondrial peptide mediated ageing mechanisms, an area where its role as a mitochondrially encoded signaling molecule makes it a uniquely valuable research tool compared to nuclear encoded metabolic peptides. Research has also examined its activity in skeletal muscle glucose regulation, obesity models, and physical performance contexts, contributing a growing and diverse literature base across metabolic, geroscience, and exercise biology research environments.

F40 Biotech formulations are stocked by Canada Steroid Depot following the same rigorous third party lab verification process applied to every product in our range. Each batch is tested for concentration accuracy and purity before being made available, with COA documentation available on request. CSD’s sourcing standards apply uniformly across all manufacturers we carry, and F40 Biotech’s MOTS-C pen meets those standards consistently. All orders ship discreetly across Canada in plain, unmarked packaging with no identifying information on the exterior.

Store at 2–8°C away from direct light. Do not freeze. Intended for research purposes only.

Commonly researched alongside Humanin and other mitochondria derived peptides in comparative mitochondrial signaling and metabolic regulation studies. Browse CSD’s full peptide range for complete sourcing.