MOTS-C Pen 60mg, 3mL Prefilled. Used to support energy, metabolism, exercise performance, and healthy body composition. Lab tested, discreetly shipped across Canada.
Format3mL Prefilled Pen
Concentration20mg/mL
Pack Size Selected: 5 Pack
Pay with Interac e-Transfer or Crypto
HPLC verified. COA on file for this batch
Ships from within Canada; No Customs
Discreet plain packaging; always
24h dispatch; Tracked Delivery
MOTS-C (Mitochondrial Open Reading Frame of the Twelve S rRNA type c) is a mitochondria derived peptide encoded within the mitochondrial genome rather than the nuclear genome; a discovery that fundamentally challenged the long held understanding that the mitochondrial genome’s coding capacity was limited to components of the oxidative phosphorylation machinery. F40 Biotech’s formulation delivers 60mg in a 3mL prefilled pen system, providing a ready to use multi dose delivery format that eliminates the reconstitution preparation steps associated with traditional lyophilized peptide vials and supports consistent dose measurement across extended research protocols.
MOTS-C’s mechanism of action centers on its role as an endogenous regulator of metabolic homeostasis through AMPK (AMP activated protein kinase) pathway activation. By translocating from the mitochondria to the nucleus in response to metabolic stress, MOTS-C directly influences nuclear gene expression. A mitochondria to nucleus signaling pathway that was not previously attributed to mitochondrially encoded peptides. AMPK activation downstream of MOTS-C signaling promotes glucose uptake, fatty acid oxidation, and mitochondrial biogenesis while suppressing anabolic pathways that consume cellular energy. A coordinated metabolic response that has generated significant research interest in studies examining insulin sensitivity, exercise mimetics, and age related metabolic decline.
MOTS-C’s research profile spans multiple areas of current interest in metabolic and longevity science. Its documented decline with age in human plasma has positioned it as a subject of research into mitochondrial peptide mediated ageing mechanisms, an area where its role as a mitochondrially encoded signaling molecule makes it a uniquely valuable research tool compared to nuclear encoded metabolic peptides. Research has also examined its activity in skeletal muscle glucose regulation, obesity models, and physical performance contexts, contributing a growing and diverse literature base across metabolic, geroscience, and exercise biology research environments.
F40 Biotech formulations are stocked by Canada Steroid Depot following the same rigorous third party lab verification process applied to every product in our range. Each batch is tested for concentration accuracy and purity before being made available, with COA documentation available on request. CSD’s sourcing standards apply uniformly across all manufacturers we carry, and F40 Biotech’s MOTS-C pen meets those standards consistently. All orders ship discreetly across Canada in plain, unmarked packaging with no identifying information on the exterior.
Store at 2–8°C away from direct light. Do not freeze. Intended for research purposes only.
Commonly researched alongside Humanin and other mitochondria derived peptides in comparative mitochondrial signaling and metabolic regulation studies. Browse CSD’s full peptide range for complete sourcing.
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondria derived peptide, a 16-amino acid peptide encoded within the mitochondrial genome rather than the nuclear genome, making it one of the first mitochondrial peptides identified with systemic hormone like activity. It is studied for its role in metabolic regulation, insulin sensitivity, exercise performance, and longevity. MOTS-c activates AMPK (AMP activated protein kinase) . The master metabolic regulator; enhancing glucose uptake, fatty acid oxidation, and mitochondrial biogenesis. Research applications include insulin resistance and type 2 diabetes metabolic research, age related metabolic decline, exercise performance and endurance enhancement, obesity and body composition research, and longevity research through mitochondrial function optimization.
The pre filled pen eliminates the reconstitution step required for lyophilized MOTS-c vials; no BAC water, no concentration calculations, and no syringe loading. The pen comes pre loaded with 60mg of MOTS-c in sterile aqueous solution at 20mg per mL, ready to inject subcutaneously with a standard pen needle. This is particularly practical for MOTS-c research protocols requiring frequent administration. The pre filled pen allows rapid, convenient subcutaneous injection without preparation time. The factory stabilized solution also maintains consistent potency throughout the pen's use period, eliminating the stability variability associated with user reconstituted lyophilized vials.
MOTS-c is administered subcutaneously typically in the abdomen, thigh, or upper arm using a standard 31–32 gauge pen needle. Common research doses range from 5–10mg per injection administered once or twice daily; at 20mg per mL, a 0.25mL injection delivers 5mg and a 0.5mL injection delivers 10mg. The 60mg total content pen provides 6–12 research doses at 5–10mg per injection. Some research protocols administer MOTS-c before exercise to investigate its acute effects on metabolic fuel utilization and exercise performance. Attach a fresh pen needle before each injection and dispose after use. Do not store with needle attached.
MOTS-c has attracted significant research interest for exercise performance applications, animal research demonstrates that exogenous MOTS-c administration produces dramatic improvements in endurance capacity comparable to exercise training itself, through AMPK activation increasing mitochondrial density, fatty acid oxidation efficiency, and glucose uptake in working muscle. MOTS-c levels naturally increase during exercise in humans. Suggesting it functions as an exercise induced mitokine that mediates some of exercise's metabolic benefits. Research is investigating whether exogenous MOTS-c can replicate or amplify these exercise induced metabolic adaptations; making it one of the most actively researched mitochondrial peptides for both performance and metabolic health applications.
Yes! This batch has been independently HPLC tested by an accredited third party laboratory confirming compound identity as MOTS-c and concentration accuracy at 60mg total content (20mg per mL). A certificate of analysis is available.
