Estradiol 2mg is an oral estrogen medication used to support healthy estrogen levels and relieve symptoms associated with low estrogen, including hot flashes and other menopausal symptoms. Each pack contains 100 tablets.
Format100 Tablets
Concentration2mg
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Estradiol 2mg tablets contain 17β estradiol, a form of estrogen that is chemically identical to the primary estrogen produced by the ovaries. Oral estradiol is a systemic estrogen therapy designed to supplement declining or insufficient estrogen levels and produce estrogenic activity throughout the body.
Estradiol works by binding to estrogen receptors in estrogen responsive tissues. These receptors influence a wide range of physiological processes, including reproductive function, temperature regulation, bone metabolism and the maintenance of vaginal and other estrogen sensitive tissues. By restoring estrogen activity, oral estradiol can help reduce moderate to severe vasomotor symptoms associated with menopause, including hot flashes, and may also be used for symptoms associated with estrogen deficiency or hypoestrogenism.
Estradiol tablets are also used clinically for estrogen deficiency associated with conditions such as hypogonadism, primary ovarian failure or surgical removal of the ovaries. Systemic estrogen can additionally play a role in maintaining bone density in appropriate postmenopausal patients, although treatment decisions depend on individual risk factors and available alternatives.
Each tablet provides 2mg of estradiol, with 100 tablets supplied per pack. Estradiol is a prescription medication in Canada, and the appropriate dose and duration of therapy should be determined by a healthcare professional. Canadian 2mg estradiol tablet formulations are available as micronized 17β estradiol, commonly supplied as estradiol hemihydrate.
Systemic estrogen therapy has important safety considerations. Estrogen can increase the risk of blood clots and certain cardiovascular events in some patients and is contraindicated in several conditions, including certain estrogen dependent cancers, unexplained vaginal bleeding and active or previous thromboembolic disease. In patients who have an intact uterus, a healthcare professional may also prescribe a progestogen to reduce the risk of endometrial hyperplasia and endometrial cancer associated with prolonged unopposed estrogen exposure.
Estradiol should be used only as directed by a qualified healthcare professional, with periodic reassessment to determine the appropriate dose and continued need for therapy.
Estradiol is an estrogen hormone chemically identical to 17β estradiol, the principal biologically active estrogen produced by the ovaries during the reproductive years. Each oral tablet contains 2mg of micronized estradiol, with 100 tablets supplied per package for a total of 200mg of estradiol.
Oral estradiol is a prescription estrogen used for several established medical indications, including treatment of moderate to severe menopausal vasomotor symptoms such as hot flashes, treatment of estrogen deficiency caused by hypogonadism or ovarian failure, and certain cases of postmenopausal osteoporosis prevention. Specific treatment should be individualized and supervised by a healthcare professional.
Estradiol binds to estrogen receptors in estrogen responsive tissues and influences gene expression involved in reproductive, skeletal, neuroendocrine, and metabolic function. Estradiol also provides negative feedback to the hypothalamic pituitary system, reducing elevated luteinizing hormone (LH) and follicle stimulating hormone (FSH) concentrations associated with estrogen deficiency.
Both formats provide 17β estradiol, but their delivery pathways differ. Oral estradiol is absorbed through the gastrointestinal tract and undergoes hepatic metabolism and enterohepatic recirculation, producing substantial conversion between estradiol, estrone, and their conjugates. Transdermal patches deliver estradiol through the skin directly into systemic circulation and therefore have a different pharmacokinetic profile.
Systemic estrogen therapy has clinically important risks and contraindications. Prescribing information identifies concerns including venous thromboembolism, stroke, certain estrogen dependent cancers, abnormal genital bleeding, liver disease, and pregnancy. In patients with an intact uterus, prolonged estrogen exposure without appropriate progestogen management can increase the risk of endometrial hyperplasia and cancer. Estradiol should be used under appropriate medical supervision.
