Follistatin 344 – 1mg

Follistatin 344 is a splice variant of the naturally occurring glycoprotein Follistatin, an endogenous TGF-β superfamily binding protein that functions as a potent antagonist of myostatin, activin, and several bone morphogenetic proteins (BMPs). iLab Pharma’s formulation supplies 1mg as a lyophilized vial, a standard research unit for this class of regulatory protein where precise low concentration handling and careful reconstitution are critical variables. It helps preserve structural integrity and biological activity across storage conditions until use.

Follistatin’s primary research mechanism centers on its high affinity binding and neutralization of myostatin, a TGF-β family member that functions as the principal negative regulator of skeletal muscle mass. By sequestering myostatin and preventing its receptor binding, Follistatin 344 removes the inhibitory brake on muscle growth signaling, allowing ActRII receptor mediated pathways to shift toward anabolic muscle protein synthesis activity. This myostatin antagonism mechanism has generated extensive research interest in studies examining skeletal muscle hypertrophy, muscle wasting disease models, and the regulatory balance between myostatin inhibition and muscle growth factor activity; making Follistatin one of the most studied endogenous muscle regulatory proteins in contemporary sports science and biomedical research.

The 344 splice variant designation is pharmacologically relevant in research context. Follistatin exists in two primary isoforms FS288 and FS344 with meaningfully different tissue distribution and receptor binding characteristics. FS288 carries a heparin binding domain that anchors it to cell surfaces and extracellular matrix, limiting its systemic distribution. FS344 lacks this anchoring domain, producing a more freely circulating form with broader systemic distribution following administration. A pharmacokinetic characteristic that makes FS344 the more frequently studied isoform in research examining systemic myostatin antagonism and its downstream effects on skeletal muscle across multiple muscle groups simultaneously.

iLab Pharma formulations are stocked by Canada Steroid Depot following the same rigorous third party lab verification process applied to every product in our range. Each batch is tested for concentration accuracy and purity before being made available, with COA documentation available on request. CSD’s sourcing standards apply uniformly across all manufacturers we carry, and iLab Pharma’s Follistatin 344 meets those standards consistently. All orders ship discreetly across Canada in plain, unmarked packaging with no identifying information on the exterior.

Reconstitute with bacteriostatic water prior to use. Store lyophilized peptide at 2–8°C away from direct light. Once reconstituted refrigerate and use within 28 days. Intended for research purposes only.

Commonly researched alongside IGF-DES and IGF-1 LR3 in comparative muscle regulatory pathway and anabolic signaling studies. Browse CSD’s full peptide range for complete sourcing.