KPV – 10mg

KPV is a synthetic tripeptide consisting of lysine, proline, and valine, the C terminal fragment of alpha melanocyte stimulating hormone (α-MSH) that retains the parent peptide’s anti inflammatory activity while offering a significantly smaller molecular structure with distinct pharmacokinetic characteristics. iLab Pharma’s formulation supplies 10mg as a lyophilized vial, preserving peptide structural integrity across storage conditions until reconstitution. It’s a standard practice for short sequence peptides where aqueous stability at ambient temperature is limited.

KPV’s anti inflammatory mechanism operates through two complementary pathways. Its primary activity involves direct inhibition of NF-κB, the master transcriptional regulator of pro inflammatory cytokine production. Reducing downstream expression of TNF-alpha, IL-1β, IL-6, and IL-8 in activated immune and epithelial cells. KPV also binds melanocortin receptors, particularly MC1R and MC3R, activating the same receptor mediated anti inflammatory signaling cascade as full length α-MSH but through a tripeptide fragment that is substantially more stable in biological fluids than the parent 13 amino acid peptide. This dual NF-κB inhibition and melanocortin receptor activation profile produces potent anti inflammatory activity from a minimal peptide sequence. A research characteristic that has generated specific interest in studies examining the structure activity relationship between α-MSH and its bioactive fragments.

KPV’s gastrointestinal research profile is a particularly active area of current investigation. Its small tripeptide structure demonstrates notable resistance to gastrointestinal proteolytic degradation compared to larger peptides;  a stability characteristic that has supported research into oral KPV delivery for intestinal inflammatory pathway modulation, with documented activity in inflammatory bowel disease and colitis preclinical models examining epithelial barrier function restoration and mucosal inflammation reduction. This oral stability and gut targeted anti inflammatory activity distinguishes KPV’s standalone research profile from its role as a component in CSD’s KLOW Pen and KLOW Protocol combination formats, where its NF-κB inhibition contributes the anti inflammatory dimension to the four peptide regenerative blend’s overall mechanism.

iLab Pharma formulations are stocked by Canada Steroid Depot following the same rigorous third party lab verification process applied to every product in our range. Each batch is tested for concentration accuracy and purity before being made available, with COA documentation available on request. CSD stocks KPV both as this standalone 10mg lyophilized vial and as a component of the KLOW Pen and KLOW Protocol combination formats,  giving researchers the flexibility to examine KPV’s isolated anti inflammatory mechanism or its combined activity within a multi peptide regenerative blend from a single verified Canadian supplier. All orders ship discreetly across Canada in plain, unmarked packaging with no identifying information on the exterior.

Reconstitute with bacteriostatic water prior to use. Store lyophilized peptide at 2–8°C away from direct light. Once reconstituted refrigerate and use within 28 days. Intended for research purposes only.

Commonly researched alongside BPC-157 and GHK-Cu in comparative anti inflammatory and tissue repair peptide studies. Browse CSD’s full peptide range for complete sourcing.