LL-37 is a 37 amino acid cationic antimicrobial peptide and the only known human cathelicidin. A class of host defence peptides that form a critical component of the innate immune system’s first line response to pathogen invasion. iLab Pharma’s formulation supplies 5mg as a lyophilized vial, preserving peptide structural integrity and potency across storage conditions until reconstitution, important for a cationic peptide whose amphipathic helical structure, central to its antimicrobial mechanism, requires careful storage conditions to maintain functional conformation.
LL-37’s antimicrobial mechanism operates through direct membrane disruption. Its cationic charge enables electrostatic attraction to the negatively charged membranes of bacteria, fungi, and enveloped viruses, followed by insertion into and disruption of the pathogen membrane through a carpet or toroidal pore formation model. This direct membrane disruption mechanism produces broad spectrum antimicrobial activity without the target specific receptor binding that characterizes most antibiotic compounds. A mechanistic distinction that has generated significant research interest in studies examining antimicrobial resistance, as membrane disrupting peptides face fundamentally different resistance development pathways than receptor or enzyme targeting antibiotics.
Beyond its antimicrobial activity, LL-37 carries a well documented immunomodulatory research profile that has expanded its research interest considerably beyond innate immune defense. LL-37 acts as a chemokine and cytokine modulator attracting immune cells to infection sites, promoting angiogenesis through VEGF pathway activation, stimulating wound healing through epithelial cell migration and proliferation, and modulating toll like receptor signaling to regulate the magnitude of inflammatory responses. This dual antimicrobial and immunomodulatory profile makes LL-37 a uniquely positioned research compound in studies examining the intersection of innate immunity, wound healing, and inflammatory regulation. Research areas where its status as the sole human cathelicidin gives it a distinct biological significance that synthetic antimicrobial peptides cannot replicate.
iLab Pharma formulations are stocked by Canada Steroid Depot following the same rigorous third party lab verification process applied to every product in our range. Each batch is tested for concentration accuracy and purity before being made available, with COA documentation available on request. CSD’s sourcing standards apply uniformly across all manufacturers we carry, and iLab Pharma’s LL-37 meets those standards consistently. All orders ship discreetly across Canada in plain, unmarked packaging with no identifying information on the exterior.
Reconstitute with bacteriostatic water prior to use. Store lyophilized peptide at 2–8°C away from direct light. Once reconstituted refrigerate and use within 28 days. Intended for research purposes only.
Commonly researched alongside Thymosin Alpha-1 and VIP in comparative innate immune defense and immunomodulatory peptide studies. Browse CSD’s full peptide range for complete sourcing.
